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Felodipine
Clinical data
Trade namesPlendil
AHFS/Drugs.comMonograph
MedlinePlusa692016
Pregnancy categoryUS: C (Risk not ruled out)
Routes of administrationOral
ATC codeC08CA02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability15%
MetabolismHepatic
Onset of action2.5–5 hours
Elimination half-life25 hours [1]
ExcretionRenal

Plendil side effects

The effect of this interaction appears to be minor. T-type calcium channels are most commonly found on neurons, cells with pacemaker activity and on osteocytes. The tablets can be administered without food or following a light meal not rich in fat or carbohydrate. Felodipine is effective in all grades of hypertension.

Use in Lactation: Inhibition of the initial influx of calcium decreases the contractile activity of arterial cefixime generic muscle cells and results in vasodilation. Patients with impaired hepatic function may have elevated plasma concentrations of felodipine and may respond to treatment at lower doses see Precautions.

This results from precapillary vasodilatation and is not related to any generalised fluid retention.

In patients with hypertension or angina pectoris, felodipine can plendil prescribing information used also in case of impaired left ventricular function. Sometimes the dose will be as high as 20 mg once a day. Felodipine also acts as an antagonist to the mineralcorticoid receptor by competing with aldosterone for binding and blocking aldosterone-induced coactivator recruitment of the mineralcorticoid receptor.

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These conditions can lead to severely low blood pressure. Syncopesomnolence[ Ref ] Gastrointestinal Frequency not reported:

The European Commission issued an EU-wide legally binding decision to implement these changes on 16 December It was widely accepted that CCBs target L-type calcium channels, the plendil prescribing information channel in muscle cells that mediates contraction; however, some studies have shown that felodipine also binds to and inhibits T-type calcium channels.

Plendil information
Tablet name plendil
Plendil alternative name felodipina, felodipino, renedil, feloday
Active substance felodipine, felodipine
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Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. More What is Plendil?

Insomniadepressionanxiety disorders, irritability, nervousness, libido decreased[ Ref ] Genitourinary Frequency not reported: You make Plendil without food or a light meal, but take it the same way each time. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Plendil is used to treat hypertension high blood pressure.

Should such reactions occur, they are usually transient and diminish with time. Overdosage may cause excessive peripheral vasodilation with marked hypotension and sometimes bradycardia. Felodipine improves exercise tolerance and reduces anginal attacks in patients with stable effort-induced angina pectoris.

Felodipine flonase treats not eliminated by haemodialysis. Due to the high degree of selectivity for smooth muscle in the arterioles, felodipine in therapeutic doses has no direct effect on cardiac plendil prescribing information or conduction. The long-term effects of felodipine on growth, puberty and general development have not been studied.

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Plendil prescribing information
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Felodipine

Syncopesomnolence[ Ref ] Gastrointestinal Frequency not reported: Discuss the use of grapefruit products with your doctor. Plendil is used to treat hypertension high blood pressure.

We can use our salesforce to deliver this drug to a wide spectrum of the patient population. Felodipine reduces both systolic and diastolic blood pressure and can be used in isolated systolic hypertension.

Felodipine also binds to calmodulin and inhibits calmodulin-dependent calcium release from the sarcoplasmic reticulum. Stable angina pectoris. If you are unsure about any medicine you are taking you should check with your doctor or pharmacist. Similar to other DHP CCBs, felodipine binds directly to inactive calcium channels stabilizing their inactive conformation.

Our country sites can be located in the AZ Network. The pharmacologic significance of T-type calcium channel blockade is unknown. Felodipine is a vascular selective calcium antagonist which lowers arterial blood pressure by decreasing systemic vascular resistance.

There are at least five different types of calcium channels in Homo sapiens:

  • Your blood pressure will need to be checked often and you may need other blood tests at your doctor's office
  • Keep using Plendil as directed, even if you feel well
  • In case of accompanying bradycardia, atropine 0
  • Plendil contains lactose and should not be given to patients with hereditary galactose intolerance or glucose-galactose malabsorption
  • Plendil side effects in more detail What other drugs will affect Plendil
  • Hypertension is quite predominant in China
  • Overdosage may cause excessive peripheral vasodilation with marked hypotension and sometimes bradycardia

Plendil side effects

It is not known whether Plendil will harm an unborn baby. Seek emergency medical attention or call the Poison Help line at Do not use Plendil without telling your doctor if you are breast-feeding a baby.

Call your doctor for medical advice about side effects.

For the treatment of mild to moderate essential hypertension. If necessary the dose may be further increased or another antihypertensive agent added.

These effects were attributed to the inhibitory effect of felodipine in high doses on uterine contractility. Felodipine has no effect on blood glucose levels or lipid profile.

Asthenia, warm sensation Frequency not reported: Breaking the pill may cause too much of the drug to be released at one time. What happens if I overdose?

Many drugs can interact with Plendil Felodipine improves exercise tolerance and reduces anginal attacks in patients with stable effort-induced angina pectoris
See table At therapeutic sub-toxic concentrations
Call your doctor for medical advice about side effects Do not use Plendil without telling your doctor if you are breast-feeding a baby
These include Ask your doctor about the risks and benefits involved
For the treatment of mild to moderate essential hypertension Avoid getting up too fast from a sitting or lying position
Visual disturbances[ Ref ] References 1 Plendil may also be used for other purposes not listed in this medication guide

Pharmacokinetics under Actions. Activated charcoal, if necessary gastric lavage. Active lowering of blood pressure was particularly beneficial in the subgroup of patients with diabetes mellitus or imitrex tablets.

Treatment should be started with 5 mg once daily. Overdosage Symptoms: If you are unsure about any medicine you are taking you should check with your doctor or pharmacist.

Take Plendil exactly as prescribed by your doctor. These conditions can lead to severely low blood pressure.

You may need to use blood pressure medication for the rest of your life. Skip the missed dose if it is almost time for your next scheduled dose.

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Plendil, 6 reviews:

Comment №1 about product

FDA pregnancy category C. Grapefruit and grapefruit juice may interact with Plendil and lead to potentially dangerous effects.


4 / 5 stars
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Take the missed dose as soon as you remember — pariet medicine use.


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Call your doctor for medical advice about side effects.


5 / 5 stars
Comment №4 about product

Plendil is used to treat hypertension high blood pressure.


4 / 5 stars
Comment №5 about product

Many drugs can interact with Plendil. Brush and floss your teeth regularly while taking Plendil. Breaking the pill may cause too much of the drug to be released at one time.


3 / 5 stars
Comment №6 about product

Some side effects may not be reported. Plendil can cause mild swelling of your gums, which may be avoided with good dental hygiene. This is not a complete list of Plendil side effects and others may occur.


4 / 5 stars
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